Coffee Break is recorded live on Thursday evenings. Jamar talks about general subjects and interacts with his friends as they post comments. Jamar is a friend I met through our association with the Philadelphia Cartoonist Society.
I find it helps to have a podcast playing in the background while I'm doing the work-from-home thing and Coffee Break is great for that.
Here are some others I've been listening to. You've probably heard of at least some of them:
Fresh Air with Terry Gross
WTF with Marc Maron
Conan O'Brien Needs A Friend
Ten Percent Happier
DJ Yardsale
These are too distracting for work, so I listen to them in the car:
Snap Judgment